Have caregivers of your patients with dementia asked you about driving safety, refusal to accept the diagnosis, or distressing episodes of agitation? Read about the case of Ms A to learn strategies for managing patients with Alzheimer's disease as it progresses over time.

In this review article, Nordberg and colleagues examine the role of butyrylcholinesterase (BuChE) in cholinergic signaling and neurologic conditions, such as Alzheimer’s disease. The rationale for inhibiting cholinesterases in the management of Alzheimer’s disease is discussed.

The use of biomarkers in early Alzheimer’s disease detection is growing. However, it is not clear whether sophisticated biomarker testing is more efficient than neuropsychological tests focused on memory. The goal of this study was to evaluate the predictive value of the Memory Impairment Screen (MIS), a simple and brief memory test, in elderly subjects with subjective memory loss.

Autistic disorder is characterized by qualitative impairments in reciprocal social interaction, verbal and nonverbal communication, among other characteristics.

Autism is a neurodevelopmental disorder with childhood onset characterized by atypical developments.

When Mr A, a 68-year-old man, presents to Banner Alzheimer’s Institute, his wife says his short-term memory has been declining for 3 years. Mr A is irritable and states that the things he forgets are things that he does not want to remember. In private, his wife also reports “tactless” behaviors and loss of empathy toward others. What is causing his symptoms?

This CME activity features the case of a 61-year-old woman with short-term memory deficits, word-finding difficulty, increasing repetition during conversations, and excessive worrying. Does the patient have dementia, mild cognitive impairment, or an underlying psychiatric disorder? Is she cognitively normal?

Did you know that dementia with Lewy bodies accounts for up to 35% of dementia cases? Get a summary of the diagnostic criteria and clinical features of dementia with Lewy bodies, find out about its pathology and radiographic features, and get recommendations for treating this disorder in primary care.

A vast array of idiopathic somatic complaints are common among depressed persons across the lifespan.

Headaches account for a high percentage of office visits to primary care physicians.

Parkinsonism is a neurologic syndrome that manifests as any combination of 6 cardinal features: tremor at rest, rigidity, bradykinesia/hypokinesia, flexed posture, loss of postural reflexes, and the freezing phenomenon.

Tardive dyskinesia is a well-known side effect of conventional antipsychotics. Fluvoxamine may be an effective treatment for neuropsychiatric disorders via sigma-1 receptor agonism. Here, Albayrak and colleagues report 5 cases in which fluvoxamine was beneficial for both postpsychotic depressive disorder and tardive dyskinesia in patients with schizophrenia.

Are neuromotor abnormalities a feature of psychotic illness or the result of side effects of antipsychotic medication? To answer this question, this study examined the effect of antipsychotic medication on neuromotor abnormalities in psychotic patients who had not been exposed to antipsychotic drugs.

American society has been through significant changes in our lifetime. Recent events have focused people on the stability of their employment and the continuity of their income flow.

Are you familiar with the most common pain syndromes associated with MS? In this Neurology Report, review central neuropathic and nociceptive pain symptoms frequently experienced by patients with MS, and learn which evidence-based treatments are appropriate for each type of pain.

Have you ever wondered how often multiple sclerosis (MS) is complicated by neuropsychiatric symptoms such as depression, mania, or cognitive impairment?

Spinocerebellar ataxia (SCA) is an inherited disorder of brain function characterized by progressive incoordination of gait and is often associated with poor coordination of hands, speech, and eye movements.

A retrospective review of published literature disclosed case reports of seizures following citalopram overdose.

In patients with cirrhosis, cognitive impairment may occur as a result of several mechanisms.

Read about the case of Mr A, a 70-year-old man who was admitted to the nursing home unit of a hospital on an "end of life" contract. At the beginning of his stay, he focused primarily on the chronic pain he suffered after experiencing combat and sustaining multiple accidents. The author met with Mr A and established a connection that allowed psychotherapy to be useful.

Patients with medical conditions, such as pain, inflammation, and diabetes, are at an increased risk for developing depression, and vice versa. View this virtual slide show to learn about the co-occurrence of these conditions and what that means for the treatment of your patients with depression, pain, and comorbid medical conditions.

The role played by the brain’s dopamine system in pain control has garnered attention in recent years.

In this era of exponential growth of the "metabolic syndrome" and obesity, lifestyle modifications could be a cost-effective way to improve health and quality of life.

We describe a patient in a skilled nursing facility who had symptom exacerbation of bipolar disorder while taking divalproex and olanzapine.

Read this series of Brief Reports to learn about the pathophysiology, prevalence, and consequences of shift work disorder and to discover how to diagnose this problem when you encounter it in clinical practice.

Little research exists to examine the combined roles of major depressive disorder (MDD) and insomnia in health care expenditures and impaired work function. This study by Kim and colleagues evaluated health care utilization, costs, and work productivity loss associated with insomnia in patients newly diagnosed with MDD.

We read with interest the recenetly published discussion concerning the use of atypical antipsychotic medications in the primary care setting.

Is it reasonable to assume that just about everyone becomes depressed following a stroke?

Geriatric substance abuse is a topic of growing interest; however, most of the existing literature has focused on alcohol and prescription drug abuse. Meanwhile, relatively little attention has been paid to illicit substance use among the elderly. This review attempts to define the extent of illicit drug use in the elderly and explores methods of early recognition and appropriate treatment.

The authors of this article investigated the possible anticraving efficacy of high-frequency deep transcranial magnetic stimulation of the bilateral dorsolateral prefrontal cortex in 3 patients with comorbid long-term DSM-IV-TR dysthymic disorder and alcohol use disorder.